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[Effect of reduced arterial compliance on the diastolic function of the heart]
Z A Ashour1, G el Said, S Gharieb
1Service de cardiologie, Faculté de médecine, Université du Caire, Egypte.
Background And Objective:
Reduced arterial compliance is associated with age, hypertension and left ventricular hypertrophy. It is unclear if and how reduced arterial compliance affects the diastolic properties of the heart.
Patient Population:
We examined 64 normotensive and 27 hypertensive individuals, (31 females, 60 males). Their ages ranged from 19 to 78 years (mean 43 +/- 14.7 y), BP ranged from 80/50 to 180/110 mmHg. Exclusion criteria were atrial fibrillation, coronary or peripheral vascular disease, diabetes, anemia, hypercholesterolaemia, as well as antihypertensive drug therapy.
Methods:
Diastolic function was assessed by Doppler measurement of E and A wave velocities of Mitral flow. E acceleration and deceleration slopes and times. LV mass was calculated from an M- mode echocardiogram. Arterial compliance was assessed by an automatic pulse wave velocity (PWV) measurement.
Results:
Age and PWV correlated significantly with the mitral E and A waves, the E acceleration time. E deceleration and E deceleration time. No significant correlations were found between SBP, DBP or LV mass and the parameters of diastolic function (see table).