Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Architecture of compact three alpha-helical structures]

A V Efimov1

  • 1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Russia. efimov@ipr.serpukhov.su

Bioorganicheskaia Khimiia
|September 28, 1998
PubMed
Summary

Compact three-alpha-helical structures, like hairpins and L-shapes, are stable building blocks found in many globular proteins. These fundamental protein motifs can fold independently, forming the core of small proteins and domains.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Chordoma as a neurosurgical pathology].

Arkhiv patologii·2022
Same author

[Relationship between the Interhelical Packing Angles and the Length of α-Helices in Proteins].

Molekuliarnaia biologiia·2020
Same author

[Structure and Features of Amino Acid Sequences of L-Modules in SH3-Like Folds].

Molekuliarnaia biologiia·2019
Same author

Chirality and Handedness of Protein Structures.

Biochemistry. Biokhimiia·2018
Same author

[Unique Combinations of βαβ-Units and Π-Like Modules in Proteins and Specific Features of Their Amino Acid Sequences].

Molekuliarnaia biologiia·2018
Same author

[Relationship between structure and amino acid sequence of strongly twisted and coiled β-hairpins in globular proteins].

Molekuliarnaia biologiia·2016

Area of Science:

  • Protein structure analysis
  • Computational biology
  • Biophysics

Context:

  • Globular proteins are essential for numerous biological functions.
  • Understanding protein folding and stability is crucial in molecular biology.
  • The role of small, recurring structural motifs in protein architecture is an active area of research.

Purpose:

  • To model and analyze compact spatial arrangements of three alpha helices.
  • To identify and classify fundamental three-helix structural motifs.
  • To investigate the stability and folding capabilities of these motifs.

Summary:

  • Analysis revealed that compact three-helix arrangements can be described as combinations of specific motifs, including alpha-helical hairpins, L-shaped, V-shaped, and alpha-l-alpha structures.
  • These identified motifs were found to be prevalent in existing globular proteins.
  • Many small proteins and domains were observed to be composed solely of these stable three-helix structures, suggesting their self-folding capability.

Impact:

  • This research identifies fundamental, stable structural units within proteins.
  • The findings suggest that these three-helix motifs act as independent folding units, simplifying protein structure prediction.
  • Provides a basis for understanding the assembly and stability of larger protein structures.

Related Experiment Videos