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Some controversies in planning and analysing multi-centre trials
1Department of Statistical Science, University College London, U.K.
Statistics in Medicine
|September 28, 1998
Abstract:
It is shown that a rational approach to planning multi-centre trials will lead to an unequal distribution of patients across centres. Consequently different approaches to estimation will yield different estimates. However, some such approaches are not reasonable and it is concluded that multi-centre trials are less problematic than is commonly supposed.