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Related Experiment Videos

Programmed cell death: does it play a role in Parkinson's disease?

R E Burke1, N G Kholodilov

  • 1Department of Neurology, Columbia University, New York, NY, USA.

Annals of Neurology
|September 28, 1998
PubMed
Summary

Programmed cell death (PCD) is a potential cause of neuron degeneration in Parkinson's disease (PD). Further research into the molecular basis of PCD in dopamine neurons is needed for human PD brain investigations.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Programmed cell death (PCD) is a genetically regulated process.
  • PCD is implicated in normal development and can occur in neurological diseases.
  • Dopamine neuron degeneration in Parkinson's disease (PD) may involve PCD.

Purpose of the Study:

  • To explore the hypothesis that PCD underlies neurodegeneration in Parkinson's disease (PD).
  • To review evidence for PCD in dopamine neurons in PD and related disorders.
  • To highlight the need for understanding the molecular basis of PCD in dopamine neurons.

Main Methods:

  • Review of existing literature on PCD and neurodegenerative diseases.
  • Examination of studies inducing apoptosis in animal models of parkinsonism.

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  • Analysis of findings from human PD brain investigations.

    • Main Results:

    • Apoptosis, a form of PCD, occurs naturally in dopamine neurons.
    • Apoptotic death can be induced in dopamine neurons in animal models of PD.
    • Studies in human PD brains show mixed results regarding evidence of apoptotic death.

    Conclusions:

    • PCD is a plausible mechanism for dopamine neuron loss in PD.
    • Further research requires a deeper understanding of the molecular mechanisms of PCD in dopamine neurons.
    • Molecular investigation is crucial for interpreting findings in human postmortem PD tissue.