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Updated: Sep 27, 2026
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Pseudomyxoma peritonei--a heterogenous disease
1Department of Pathology, People's Hospital, Beijing Medical University, China.
Objective:
To evaluate the origin of pseudomyxoma peritonei (PMP) in Chinese women.
Methods:
The clinicopathologic features of 15 cases of PMP were reviewed. Immunostaining using antibodies for CK7 and CK20 was performed in the ovarian, appendiceal and peritoneal lesions of these cases.
Results:
Appendiceal pathology was documented in five cases, including four mucinous cystadenoma and one simple mucocele. Eight ovarian tumors were found, including seven mucinous cystadenocarcinomas of low malignant potential and one mucinous cystadenoma. Synchronous ovarian and appendiceal lesions were discovered in three cases. One patient had adenocarcinoma of the pancreas. The origin of mucin production was not known in four cases with metastatic adenocarcinoma found in two of them. Immunoreactivity for CK20 was demonstrated in the tissues derived from the peritoneum, ovary, appendix and pancreas while only 23% (3 out of 13 women) of the peritoneal lesions and 33% (2 out of 6 women) of the ovarian tumors were immunoreactive for CK7.
Conclusions:
PMP is a heterogeneous lesion, which may develop from mucinous metaplasia of the peritoneum or from appendiceal, or ovarian lesions. Careful examination of the ovary and appendix with performance of appendectomy is advised in every case of PMP. Immunohistochemical examination of the peritoneal, ovarian or appendiceal lesions using antibodies, in particular that for CK7 would help in defining the origin of mucin production.
Insights
Pseudomyxoma peritonei (PMP) in Chinese women originates from diverse sources, including ovarian and appendiceal lesions. Immunohistochemistry, particularly CK7 staining, aids in determining the mucin production origin.
Area of Science:
- Gastroenterology
- Gynecologic Oncology
- Pathology
Background:
- Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous ascites and gelatinous implants.
- Determining the primary origin of PMP is crucial for appropriate management and prognosis.
Purpose of the Study:
- To investigate the origin of pseudomyxoma peritonei (PMP) in a cohort of Chinese women.
- To evaluate the utility of immunohistochemical markers in identifying the PMP source.
Main Methods:
- Retrospective review of 15 PMP cases in Chinese women.
- Immunohistochemical analysis of peritoneal, ovarian, and appendiceal lesions using CK7 and CK20 antibodies.
Main Results:
- Appendiceal pathology was identified in 5 cases (mucinous cystadenoma, mucocele).
- Ovarian tumors were present in 8 cases (mucinous cystadenocarcinomas, mucinous cystadenoma).
- CK20 was positive in most tissues, while CK7 showed limited reactivity in peritoneal (23%) and ovarian (33%) lesions.
Conclusions:
- PMP is a heterogeneous condition with origins in the peritoneum, appendix, or ovaries.
- Thorough examination of the appendix and ovaries, including appendectomy, is recommended.
- Immunohistochemistry, especially CK7 staining, is valuable for pinpointing the origin of mucin production in PMP.
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