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Pseudomyxoma peritonei--a heterogenous disease

D H Shen1, T Y Ng, U S Khoo

  • 1Department of Pathology, People's Hospital, Beijing Medical University, China.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|September 28, 1998
PubMed
Summary

Pseudomyxoma peritonei (PMP) in Chinese women originates from diverse sources, including ovarian and appendiceal lesions. Immunohistochemistry, particularly CK7 staining, aids in determining the mucin production origin.

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Area of Science:

  • Gastroenterology
  • Gynecologic Oncology
  • Pathology

Background:

  • Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous ascites and gelatinous implants.
  • Determining the primary origin of PMP is crucial for appropriate management and prognosis.

Purpose of the Study:

  • To investigate the origin of pseudomyxoma peritonei (PMP) in a cohort of Chinese women.
  • To evaluate the utility of immunohistochemical markers in identifying the PMP source.

Main Methods:

  • Retrospective review of 15 PMP cases in Chinese women.
  • Immunohistochemical analysis of peritoneal, ovarian, and appendiceal lesions using CK7 and CK20 antibodies.

Main Results:

  • Appendiceal pathology was identified in 5 cases (mucinous cystadenoma, mucocele).

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  • Ovarian tumors were present in 8 cases (mucinous cystadenocarcinomas, mucinous cystadenoma).
  • CK20 was positive in most tissues, while CK7 showed limited reactivity in peritoneal (23%) and ovarian (33%) lesions.

    • Conclusions:

    • PMP is a heterogeneous condition with origins in the peritoneum, appendix, or ovaries.
    • Thorough examination of the appendix and ovaries, including appendectomy, is recommended.
    • Immunohistochemistry, especially CK7 staining, is valuable for pinpointing the origin of mucin production in PMP.