Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carotid body I1-imidazoline receptors: binding, visualization and modulatory function

P Ernsberger1, Y R Kou, N R Prabhakar

  • 1Department of Nutrition, Case Western Reserve School of Medicine, Cleveland, OH 44106-4906, USA. pre@po.cwru.edu

Respiration Physiology
|September 28, 1998
PubMed
Summary

The carotid body expresses I1-imidazoline receptors that may enhance chemosensory activity, unlike inhibitory alpha2-adrenergic receptors. This finding offers new insights into cardiorespiratory regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of cancer development on the risk of mycobacterial diseases among rheumatoid arthritis patients.

Epidemiology and infection·2017
Same author

Role of transient receptor potential vanilloid 1 in regulating erythropoietin-induced activation of endothelial nitric oxide synthase.

Acta physiologica (Oxford, England)·2016
Same author

Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia.

American journal of physiology. Cell physiology·2015
Same author

Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.

Acta physiologica (Oxford, England)·2012
Same author

Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke.

Acta physiologica (Oxford, England)·2012
Same author

Risk of adverse perinatal outcomes with antithyroid treatment during pregnancy: a nationwide population-based study.

BJOG : an international journal of obstetrics and gynaecology·2011

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Respiratory Physiology

Background:

  • The carotid body plays a crucial role in cardiorespiratory regulation.
  • Neurotransmitter receptors significantly influence carotid body function.
  • Imidazoline receptors are implicated in central cardiorespiratory control.

Purpose of the Study:

  • To investigate the presence and function of I1-imidazoline and alpha2-adrenergic receptors in the carotid body.
  • To determine the role of these receptors in modulating chemosensory discharge.

Main Methods:

  • Characterization of specific [125I]p-iodoclonidine binding to carotid body membranes in cats and rabbits.
  • Autoradiographic visualization of binding site distribution.
  • Assessment of chemosensory activity following alpha2-adrenergic blockade and clonidine administration in cats.

Related Experiment Videos

Main Results:

  • Specific [125I]p-iodoclonidine binding was partially inhibited by alpha2-adrenergic agents, indicating the presence of both I1-imidazoline and alpha2-adrenergic sites.
  • Autoradiography confirmed intense labeling in the cat carotid body.
  • Clonidine facilitated chemosensory activity, especially under hypoxia, after alpha2-adrenergic blockade.

Conclusions:

  • I1-imidazoline receptors are expressed in the carotid body.
  • These receptors may potentiate chemosensory discharge, contrasting with the inhibitory effects of alpha2-adrenergic receptors.
  • The findings suggest a novel role for I1-imidazoline receptors in carotid body function and cardiorespiratory control.