Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Total androgen blockade--concept, theory, method and clinical application]

S Ozono1, Y Hirao

  • 1Department of Urology, Nara Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 29, 1998
PubMed
Summary

Total androgen blockade (TAB), combining antiandrogens with castration or LH-RH analogues, shows survival benefits for advanced prostate cancer. Further research is needed to clarify the role of this therapeutic strategy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

39 Efficacy of roscovitine and dibutyryl cAMP to block premature meiosis in porcine oocytes vitrified at the germinal vesicle stage and their effect on subsequent embryo development.

Reproduction, fertility, and development·2022
Same author

Relative importance of initial conditions on outflows from multiple fans.

Physical review. E·2019
Same author

Phase I/II study of S-1 in combination with sorafenib for metastatic renal cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Randomised phase III study of neoadjuvant chemotherapy with methotrexate, doxorubicin, vinblastine and cisplatin followed by radical cystectomy compared with radical cystectomy alone for muscle-invasive bladder cancer: Japan Clinical Oncology Group Study JCOG0209.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2.

Clinical genetics·2013
Same author

Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma.

British journal of cancer·2011

Area of Science:

  • Oncology
  • Endocrinology
  • Pharmacology

Context:

  • Advanced prostate cancer treatment often involves hormonal therapies.
  • Total androgen blockade (TAB) is a strategy combining antiandrogens with castration or GnRH analogues.
  • Investigational and clinical data are emerging for TAB in prostate cancer management.

Purpose:

  • To review the concept, theory, methodology, and clinical applications of total androgen blockade (TAB).
  • To evaluate the evidence supporting the efficacy of TAB compared to standard treatments.
  • To identify ongoing controversies and future research directions for TAB.

Summary:

  • TAB aims to suppress both testicular and adrenal androgen production, potentially offering superior outcomes to standard hormonal management.

Related Experiment Videos

  • Clinical studies suggest a survival advantage for TAB over luteinizing hormone-releasing hormone (LH-RH) analogue monotherapy.
  • Commonly used agents in Japan include Chlormadinone acetate or Flutamide combined with Leuprorelin acetate or Goserelin acetate.

    • Impact:

    • TAB represents a potential therapeutic advancement for advanced prostate cancer.
    • Understanding the optimal role of TAB requires further investigation to resolve current controversies.
    • Future studies are crucial for defining the definitive place of TAB in prostate cancer treatment protocols.