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Related Experiment Videos

[Trend in genetic medicine]

Y Shoji1, Y Mizushima

  • 1Institute of Medical Science, St. Marianna University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 29, 1998
PubMed
Summary

Genetic medicines show promise as pharmaceuticals but face delivery challenges. Current research focuses on chemical modifications and carriers to improve efficiency, particularly for antisense oligonucleotides and aptamers.

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Area of Science:

  • Pharmacology and molecular biology
  • Biotechnology and drug delivery

Context:

  • Genetic medicines, including antisense oligonucleotides and aptamers, are being developed as novel pharmaceutical agents.
  • Significant challenges in delivery efficiency have hindered the clinical translation of genetic medicines over the past decade.
  • Ongoing research explores chemical modifications and advanced drug carriers to enhance the biological activity and delivery of genetic medicines.

Purpose:

  • To review current trends and advancements in the field of genetic medicines.
  • To highlight the progress and challenges associated with antisense oligonucleotides and aptamers.
  • To discuss strategies for improving the delivery efficiency of genetic medicines.

Summary:

  • Genetic medicines, such as antisense oligonucleotides and aptamers, are under investigation for therapeutic applications.
  • Delivery efficiency remains a critical hurdle, with ongoing efforts to overcome it through chemical modifications and novel carrier systems.
  • Several genetic medicine candidates are progressing through clinical trials, indicating significant therapeutic potential.

Impact:

  • Advances in genetic medicine delivery could lead to more effective treatments for various diseases.
  • The development of improved antisense oligonucleotides and aptamers may offer new therapeutic options.
  • Successful clinical translation of these genetic medicines could revolutionize pharmaceutical approaches.

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