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Related Experiment Videos

Are extant lungfish neotenic?

J M Joss1

  • 1School of Biological Sciences, Macquarie University, Sydney, New South Wales, Australia. JJOSS@RNA.BIO.MQ.EDU.AU

Clinical and Experimental Pharmacology & Physiology
|September 29, 1998
PubMed
Summary
This summary is machine-generated.

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Lungfish development up to one year shows similarities to amphibian premetamorphosis, suggesting potential neoteny. However, the pituitary-thyroid axis lacks responsiveness, requiring further study in later life stages.

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Comparative Physiology

Background:

  • The thyroid axis is crucial for amphibian metamorphosis.
  • Neoteny, or the retention of juvenile features into adulthood, is observed in some amphibians (urodeles).
  • Lungfish (Neoceratodus forsteri) development offers a model to investigate evolutionary aspects of thyroid function and neoteny.

Purpose of the Study:

  • To investigate the development and function of the thyroid axis in lungfish.
  • To determine if lungfish exhibit developmental patterns similar to neotenic amphibians.
  • To explore the pituitary-thyroid relationship during early lungfish development.

Main Methods:

  • Immunocytochemical analysis of pituitary cell types in developing lungfish.

Related Experiment Videos

  • Assessment of thyroidal iodine uptake following thyroid inhibitor treatment.
  • Evaluation of lungfish response to exogenous human thyroid-stimulating hormone (TSH).
  • Identification of thyroid hormone receptor types in lungfish liver.

    • Main Results:

    • The lungfish pituitary develops but remains unconnected to the hypothalamus during the first year.
    • No induced thyroidal iodine uptake was observed with thyroid inhibitors, indicating a lack of TSH activity.
    • Exogenous human TSH did not elicit a response in the lungfish.
    • Thyroid hormone receptors in the liver are predominantly of the alpha type.

    Conclusions:

    • Lungfish development up to one year resembles amphibian premetamorphosis.
    • The observed pituitary-thyroid axis characteristics are consistent with neoteny but do not confirm it.
    • Further research on later developmental stages is necessary to definitively establish neoteny in lungfish.