Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The specification of olfactory neurons

F A Ebrahimi1, A Chess

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA.

Current Opinion in Neurobiology
|September 30, 1998
PubMed
Summary

Olfactory receptor expression dictates neural identity in mice, but not in C. elegans. This difference highlights varying mechanisms in neural development across species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary complications in primary hypogammaglobulinemia: a survey by high resolution CT scan.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2006
Same author

Dscam-mediated self- versus non-self-recognition by individual neurons.

Cold Spring Harbor symposia on quantitative biology·2005
Same author

Asynchronous replication and allelic exclusion in the immune system.

Nature·2001
Same author

Convergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe.

Nature neuroscience·2000
Same author

Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis.

Current biology : CB·2000
Same author

Odorant receptors: axon contact-mediated diversity.

Current biology : CB·2000

Area of Science:

  • Neuroscience
  • Olfactory System Biology
  • Developmental Biology

Background:

  • Odorant receptor (OR) expression is crucial for olfactory system development.
  • Vertebrate and invertebrate olfactory systems exhibit distinct developmental strategies.

Purpose of the Study:

  • To compare the role of odorant receptor expression in neural identity specification between vertebrates (mice) and invertebrates (C. elegans).
  • To elucidate the mechanisms underlying neuronal identity determination in the olfactory system.

Main Methods:

  • Comparative analysis of gene expression patterns in olfactory neurons.
  • Investigating the link between specific olfactory receptor expression and neuronal fate in model organisms.

Main Results:

  • In mice, a single expressed olfactory receptor is essential for specifying neuronal identity and guiding axons.
  • In Caenorhabditis elegans (C. elegans), neuronal identity appears to be determined independently of olfactory receptor expression.

Conclusions:

  • Olfactory receptor expression plays a critical, instructive role in vertebrate olfactory neural development.
  • Invertebrate olfactory systems, like C. elegans, may utilize alternative pathways for neuronal identity specification, independent of receptor signaling.

Related Experiment Videos