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[Oncogenetics: how far, and what for?]

C Noguès1

  • 1Centre René-Huguenin, Saint-Cloud.

Bulletin Du Cancer
|September 30, 1998
PubMed
Summary

Oncogenetics, the study of inherited cancer susceptibility, is rapidly evolving. Current debates focus on the appropriate application and scope of genetic testing for adult-onset conditions.

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Area of Science:

  • Oncogenetics: A rapidly advancing interdisciplinary field merging research and clinical practice.
  • Focus on inherited susceptibility genes for common adult malignancies.
  • Exploration of predictive medicine and genetic testing for adult-onset disorders.

Context:

  • Oncogenetics bridges the gap between research discoveries and clinical genetic testing services.
  • Significant public and professional attention, transitioning from enthusiasm to critical evaluation.
  • Breast cancer susceptibility serves as a key example of ongoing oncogenetics controversies.

Purpose:

  • To address the evolving landscape of oncogenetics and cancer genetic testing.
  • To navigate the complexities of "predictive" medicine and genetic susceptibility assessment.
  • To inform the ongoing debate on the appropriate use and extent of genetic testing.

Summary:

  • The field of oncogenetics is rapidly expanding, focusing on genes linked to inherited susceptibility for adult cancers.
  • Current discussions emphasize conditional acceptance of genetic testing, shifting from a simple "for or against" stance.
  • Key considerations include the extent and purpose of genetic testing, with emerging guidelines addressing these issues.

Impact:

  • Highlights the critical need for comprehensive assessment of genetic testing outcomes.
  • Stresses the importance of a multidisciplinary approach for medical management in oncogenetics.
  • Underscores the necessity of patient-centered research to understand the psychological and social impacts of genetic testing.

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