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Related Experiment Videos

[Clinical differences between variant and non-variant angina pectoris]

S Sueda1, K Mineoi, T Kondo

  • 1Department of Cardiology, Takanoko Hospital, Ehime.

Journal of Cardiology
|September 30, 1998
PubMed
Summary

Variant angina pectoris with ST segment elevation and non-variant angina pectoris without ST segment elevation share similar clinical characteristics. However, variant angina shows increased spasm tendency and more fixed coronary stenosis.

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Area of Science:

  • Cardiology
  • Vascular Medicine
  • Clinical Research

Background:

  • Distinguishing between variant angina pectoris with ST segment elevation and non-variant angina pectoris without ST segment elevation is crucial for effective treatment.
  • Vasospastic angina encompasses both ST-elevation and non-ST-elevation forms, necessitating a clear understanding of their clinical profiles.

Purpose of the Study:

  • To compare the clinical characteristics of patients with variant angina pectoris (ST segment elevation) and non-variant angina pectoris (no ST segment elevation).
  • To identify potential differences in coronary risk factors, procedural outcomes, and provocation test responses between the two angina types.

Main Methods:

  • A spasm provocation test using acetylcholine or ergonovine was conducted on 192 patients with vasospastic angina.

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  • Clinical data, including coronary risk factors, lipid profiles, arrhythmias, stenosis severity, and provocation test results, were analyzed.
  • Fifty-five patients with variant angina and 124 with non-variant angina were compared.

    • Main Results:

    • Patients with variant angina exhibited a higher incidence of fixed coronary stenosis (p < 0.01).
    • Variant angina patients required more percutaneous transluminal coronary angioplasty procedures.
    • Lower doses of intracoronary acetylcholine were needed to induce spasm in variant angina patients, with a shorter duration from chest pain onset (p < 0.01).

    Conclusions:

    • Variant angina pectoris and non-variant angina pectoris share many clinical characteristics.
    • Variant angina tends to be associated with greater spasm sensitivity and more significant fixed coronary artery stenosis.