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Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis

A O Quartero1, N J de Wit, A C Lodder

  • 1Department of General Practice, Universiteit Utrecht, The Netherlands.

Digestive Diseases and Sciences
|September 30, 1998
PubMed
Summary

Patients with functional dyspepsia experience significantly slower gastric emptying compared to healthy individuals. This meta-analysis found that nearly 40% of functional dyspepsia patients exhibit delayed solid food emptying.

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Area of Science:

  • Gastroenterology
  • Digestive Physiology
  • Medical Statistics

Background:

  • Functional dyspepsia is a prevalent gastrointestinal disorder with complex causes.
  • The specific contribution of impaired gastric motility to functional dyspepsia pathophysiology requires clarification.

Purpose of the Study:

  • To quantitatively assess the association between delayed gastric emptying and functional dyspepsia.
  • To synthesize existing evidence using a meta-analytic methodology.

Main Methods:

  • Systematic literature search of Medline and Embase databases (1983-1996).
  • Inclusion of studies measuring scintigraphic solid-phase gastric emptying in functional dyspepsia patients and controls.
  • Meta-analysis of data from 17 studies, encompassing 868 patients and 397 controls.

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Main Results:

  • Gastric emptying was found to be 1.46 times slower in functional dyspepsia patients compared to controls.
  • The prevalence of abnormally slow gastric emptying was estimated at 37-39% among patients.
  • A significant delay in solid gastric emptying was observed in a substantial proportion of functional dyspepsia cases.

Conclusions:

  • Solid gastric emptying is significantly delayed in patients diagnosed with functional dyspepsia.
  • Approximately 40% of individuals with functional dyspepsia present with impaired gastric emptying.
  • Gastric motility disturbances are a key factor in the pathophysiology of functional dyspepsia.