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Regional cerebral blood flow in pediatric moyamoya disease: age-dependent decline in specific regions
T Ishikawa1, N Tanaka, K Houkin
1Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan. teddyish@asahikawa.jrc.or.jp
Insights
This study examined regional cerebral blood flow (rCBF) in pediatric surgical patients. Post-surgery, rCBF increased in younger children, showing age-related changes in brain blood flow.
Area of Science:
- Pediatric Neurology
- Neurosurgery
- Medical Imaging
Background:
- Regional cerebral blood flow (rCBF) changes in pediatric patients undergoing surgery are not fully understood.
- Age-related variations in brain perfusion can impact surgical outcomes and recovery.
Purpose of the Study:
- To investigate preoperative and postoperative rCBF in pediatric patients after surgical treatment.
- To analyze the correlation between rCBF and age in different brain regions before and after surgery.
Main Methods:
- Utilized the 133Xe inhalation method and single photon emission computed tomography (SPECT) to measure rCBF.
- Examined 13 pediatric patients (ages 4-13) pre- and post-surgery, and 13 healthy controls (ages 6-21).
- Measured rCBF in the operculum, frontal, parietal, and occipital lobes.
Main Results:
- Preoperative rCBF showed a significant negative correlation with age in the parietal and occipital lobes.
- Postoperative rCBF significantly increased in patients aged 5 years or less.
- Postoperative rCBF demonstrated significant negative correlations with age across all measured brain regions.
Conclusions:
- Surgical treatment impacts rCBF in pediatric patients, particularly in younger individuals.
- Age is a significant factor influencing rCBF changes following surgery in pediatric patients.
- These findings highlight the dynamic nature of brain perfusion in pediatric surgical recovery.
Abstract:
Thirteen pediatric patients (ages 4-13 years) who underwent surgical treatment were examined regarding their rCBF in the preoperative periods. The postoperative rCBF was measured 39 times in these 13 patients. Thirteen healthy normal subjects (ages from 6 to 21 years) were also examined. The rCBF in the operculum and in the frontal, parietal, and occipital lobes was measured with 133Xe inhalation method and single photon emission computed tomography. In the parietal and occipital lobes, the preoperative rCBF had a negative and significant correlation with their ages, but not in the operculum or frontal lobe. However, subsequent to the surgical treatment, the rCBF increased significantly in the patients 5 years old or less, and then post-operative rCBF values had significant negative correlations with age in each region.