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A close family resemblance: the importance of structure in understanding cytochromes P450
1Department of Biochemistry The University of Texas Southwestern Medical Center, Dallas 5323 Harry Hines Blvd, Dallas, TX 75235-9038, USA. Bill@P450BM3.swmed.edu
Structure (London, England : 1993)
|October 1, 1998
Abstract:
Cytochromes P450 comprise a very large superfamily of hemeproteins which generally monooxygenate hydrophobic compounds. P450s appear to have a common conserved structural core, yet are variable in regions involved in substrate recognition and binding, and in redox-partner binding. These differences can be identified by an analysis in which structural alignments and homology models are used to compare the various classes and families of P450s.