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Visualization of Recombinant DNA and Protein Complexes Using Atomic Force Microscopy
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Visualization of Recombinant DNA and Protein Complexes Using Atomic Force Microscopy

Published on: July 18, 2011

A convenient method of aligning large DNA molecules on bare mica surfaces for atomic force microscopy

J Li1, C Bai, C Wang

  • 1The Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080, China and The Institute of Biophysics, the Chinese Academy of Sciences, Beijing 100171, China.

Nucleic Acids Research
|October 1, 1998
PubMed

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Atomic Force Microscopy01:08

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...