Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calculation of apparent diffusion coefficients (ADCs) in brain using two-point and six-point methods

J H Burdette1, A D Elster, P E Ricci

  • 1Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1088, USA.

Journal of Computer Assisted Tomography
|October 1, 1998
PubMed
Summary

Calculating brain apparent diffusion coefficients (ADCs) with a simple two-point MRI technique is highly accurate. This method shows minimal error compared to a more complex six-point technique, simplifying diffusion imaging analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Network science and the effects of music preference on functional brain connectivity: from Beethoven to Eminem.

Scientific reports·2014
Same author

Motor cortical functional geometry in cerebral palsy and its relationship to disability.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2011
Same author

Does MR perfusion imaging impact management decisions for patients with brain tumors? A prospective study.

AJNR. American journal of neuroradiology·2011
Same author

Pulsed arterial spin-labeled MR imaging evaluation of tuberous sclerosis.

AJNR. American journal of neuroradiology·2009
Same author

Hypercapnia-induced cerebral hyperperfusion: an underrecognized clinical entity.

AJNR. American journal of neuroradiology·2008
Same author

Migraine associated cerebral hyperperfusion with arterial spin-labeled MR imaging.

AJNR. American journal of neuroradiology·2008

Area of Science:

  • Radiology
  • Medical Imaging
  • Neuroscience

Background:

  • Diffusion-weighted magnetic resonance imaging (DW-MRI) is crucial for assessing brain tissue microstructure.
  • Apparent diffusion coefficients (ADCs) quantify water diffusion in tissues, aiding in disease diagnosis.
  • Accurate ADC calculation is vital for reliable interpretation of DW-MRI findings.

Purpose of the Study:

  • To compare the accuracy of a simplified two-point regression technique versus a comprehensive six-point technique for calculating brain ADCs.
  • To determine the reliability of using fewer data points in ADC estimation from DW-MRI.

Main Methods:

  • Echo planar diffusion-weighted MRI was performed at 1.5 T on 10 subjects.
  • Measurements were acquired at standard and pathologic intracranial locations using b values of 1, 100, 200, 500, 800, and 1,000 s/mm2.

Related Experiment Videos

  • ADCs were calculated using both a six-point nonlinear regression and a two-point linear estimation method.

    • Main Results:

    • A very high correlation (R2 = 0.999) was observed between the two-point and six-point ADC calculation methods.
    • The mean percentage difference between the two methods was minimal, at only 0.84%.
    • These findings indicate strong agreement between the simplified and comprehensive ADC estimation techniques.

    Conclusions:

    • The two-point technique provides a highly accurate and reliable method for estimating brain ADCs.
    • This simplified approach can potentially streamline DW-MRI analysis without significant loss of accuracy.
    • The findings support the use of the two-point technique for routine clinical applications requiring ADC measurements.