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[Laboratory follow-up in menopause]

M Groussin-Weyland1, Y Badonnel

  • 1Clinique universitaire de gynécologie-obstétriqué, Nancy.

Annales De Biologie Clinique
|October 1, 1998
PubMed
Summary

Menopause management involves biological monitoring to assess risks and guide hormone therapy. Regular biological follow-up is crucial for detecting metabolic diseases and preventing long-term health issues like osteoporosis.

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Area of Science:

  • Reproductive endocrinology
  • Clinical biochemistry
  • Preventive medicine

Context:

  • Menopause, characterized by estrogen deficiency, impacts women's metabolism, cardiovascular health, and bone density.
  • Hormone replacement therapy (HRT) is increasingly used to manage menopausal symptoms and prevent long-term complications.
  • The role of biological monitoring in managing menopausal women, with or without HRT, requires clarification.

Purpose:

  • To define the role of biological assays in the diagnosis and management of menopause.
  • To evaluate the utility of biological markers in guiding HRT choices and monitoring treatment efficacy.
  • To emphasize the importance of regular biological follow-up for early detection of metabolic abnormalities and osteoporosis risk.

Summary:

  • While clinical observation is primary for menopause diagnosis, plasmatic FSH and estradiol assays aid in specific cases.
  • Biological assays are vital before initiating HRT to establish a metabolic profile, select appropriate estrogenotherapy (oral vs. percutaneous), and identify contraindications.
  • Biological markers for osteoporosis risk can encourage treatment initiation or continuation. Post-menopause, regular biological follow-up, alongside screenings like mammography and cervical smears, is recommended for all women, irrespective of HRT status.

Impact:

  • Establishes the critical role of biological monitoring in personalized menopause care.
  • Highlights the use of biomarkers for informed HRT decisions and osteoporosis prevention.
  • Promotes proactive health management in post-menopausal women for improved quality of life.

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