Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Transgenic mouse models. Their interest in thyroid tumors]

C Ledent1, B Franc, M Parmentier

  • 1IRIBHN, Bruxelles, Belgique.

Archives D'Anatomie Et De Cytologie Pathologiques
|October 1, 1998
PubMed
Summary

Transgenic mouse models reveal critical roles for specific signaling pathways and tumor suppressor genes in thyroid disease development. These models illuminate mechanisms driving hyperthyroidism, goiter, and thyroid cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Qualitative longitudinal research in vocational psychology: a methodological approach to enhance the study of contemporary careers.

International journal for educational and vocational guidance·2026
Same author

Unsupervised Learning in PET Radiomics.

IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium·2019
Same author

Marijuana smoke induces severe pulmonary hyperresponsiveness, inflammation, and emphysema in a predictive mouse model not via CB1 receptor activation.

American journal of physiology. Lung cellular and molecular physiology·2017
Same author

Behavioral and neurochemical characterization of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2015
Same author

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.

Molecular psychiatry·2015
Same author

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.

Molecular psychiatry·2014

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Context:

  • Thyroid diseases encompass a range of conditions affecting thyroid function and structure.
  • Understanding the molecular mechanisms underlying thyroid tumorigenesis is crucial for developing targeted therapies.

Purpose:

  • To generate and characterize novel mouse transgenic models of thyroid disease.
  • To elucidate the in vivo roles of specific signaling pathways (cAMP, IP3-CA++) and tumor suppressor genes (RB1) in thyroid cell function, proliferation, and malignancy.

Summary:

  • Transgenic mice expressing adenosine A2a receptor or mutant alpha 1B adrenergic receptor developed hyperthyroidism and goiter due to constitutive cAMP cascade activation.
  • Expression of SV40 large T antigen led to aggressive thyroid tumors, while E7 oncoprotein of HPV16 inhibited RB1, causing differentiated goiter and malignant lesions.

Impact:

  • These mouse models provide valuable tools for studying thyroid diseases, including autonomous hyperfunctional adenoma and familial hyperthyroidism.
  • The findings highlight the essential role of RB1 in controlling thyroid cell proliferation and suggest pathways involved in thyroid cancer development.

Related Experiment Videos