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[Cutaneous malacoplakia. An immunohistochemical and ultrastructural case study]

A Chevallier1, V Battaglione, C Brunner

  • 1Service d'Anatomie Pathologique, Hôpital Pasteur, CHU de Nice, France.

Archives D'Anatomie Et De Cytologie Pathologiques
|October 1, 1998
PubMed
Summary

This case study details a rare thigh cutaneous malacoplakia in a 70-year-old man. Successful treatment involved surgical excision and antibiotics, highlighting diagnostic methods for this uncommon condition.

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Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Cutaneous malacoplakia is a rare condition, typically affecting the perineal area.
  • It often occurs in individuals with compromised immune systems.
  • This report presents an unusual thigh localization of the disease.

Observation:

  • A voluminous thigh lesion was observed in a 70-year-old male patient with a history of myelodysplasia.
  • Histological examination revealed a dermo-hypodermal granuloma with Von Hansemann cells and Michaelis-Gutmann bodies.
  • Immunohistochemical and ultrastructural studies confirmed histiocytic infiltration and identified Escherichia coli bacteria.

Findings:

  • The case presented a rare thigh manifestation of cutaneous malacoplakia.
  • Diagnostic confirmation relied on immunohistochemical and ultrastructural analyses due to difficulties in identifying Michaelis-Gutmann bodies via light microscopy.

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  • The causative agent was identified as Escherichia coli.

    • Implications:

    • This case underscores the importance of advanced diagnostic techniques (immunohistochemistry, ultrastructural analysis) for diagnosing rare cutaneous malacoplakia.
    • It highlights that cutaneous malacoplakia can occur in unusual locations beyond the perineum.
    • Prompt diagnosis and treatment, including surgical excision and antibiotics, led to a favorable outcome.