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Related Experiment Videos

Right ventricular volume characteristics in ventricular septal defect

T P Graham, G F Atwood, R J Boucek

    Circulation
    |November 1, 1976
    PubMed
    Summary

    In patients with large ventricular septal defects (VSDs), the right ventricle (RV) shows significantly increased end-diastolic volume. This RV volume augmentation correlates with left-to-right shunting, impacting overall cardiac output.

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    Area of Science:

    • Cardiology
    • Pediatric Cardiology
    • Medical Imaging

    Background:

    • Ventricular septal defects (VSDs) are common congenital heart abnormalities.
    • Left-to-right shunting in VSDs can lead to volume overload in the right ventricle (RV).
    • Understanding RV volume changes is crucial for managing VSD patients.

    Purpose of the Study:

    • To assess right and left ventricular volume characteristics in patients with isolated VSDs.
    • To correlate RV volume changes with the degree of left-to-right shunting.
    • To investigate the impact of shunting on RV end-diastolic volume and output.

    Main Methods:

    • Biplane cineangiocardiography was used to determine ventricular volumes.
    • 37 patients with isolated VSDs were categorized by shunt severity: small (<35%), moderate (35-49%), and large (>50%).

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  • RV and LV end-diastolic volumes and RV ejection fraction were analyzed.

    • Main Results:

    • Significant RV end-diastolic volume augmentation (159% of normal) was observed in 15/20 patients with large shunts.
    • RV volume increase was proportional to LV end-diastolic volume increase.
    • RV ejection fraction remained normal, but RV output increased with larger shunts.

    Conclusions:

    • Substantial RV end-diastolic volume augmentation occurs in VSD patients with large left-to-right shunts.
    • This augmentation is likely due to continuous diastolic and isovolumic shunting from the left to the right ventricle.
    • RV volume changes are a key indicator of shunt severity in VSDs.