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Related Experiment Videos

How to avoid multiple pregnancies in assisted reproduction

J Cohen1

  • 1Centre de Stérilité de l'Hôpital de sèvres, Paris, France.

Human Reproduction (Oxford, England)
|October 2, 1998
PubMed
Summary

Assisted reproduction leads to high rates of multiple pregnancies, with 3.85% of triplets or more resulting in live births. Reducing these high-order multiple pregnancies is crucial for improving obstetric and neonatal outcomes in fertility treatments.

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Area of Science:

  • Reproductive Medicine
  • Obstetrics
  • Neonatology

Background:

  • Assisted reproductive technology (ART) significantly increases the likelihood of multiple pregnancies.
  • High-order multiple births (triplets and above) are associated with increased obstetric and neonatal risks.

Purpose of the Study:

  • To analyze the international rates of triplet or higher-order pregnancies following assisted reproduction.
  • To evaluate the obstetric and neonatal outcomes associated with twin and triplet gestations.
  • To emphasize the importance of reducing multiple pregnancies in ART centers.

Main Methods:

  • Data compilation of international rates of triplet or higher-order pregnancies at conception, pre-reduction, and birth.
  • Review of obstetric and neonatal outcomes for twin and triplet pregnancies.

Main Results:

  • International conception rates for triplet or higher-order pregnancies stand at 7.3%.
  • Rates decrease to 6.5% before selective reduction and 3.85% at birth.
  • Obstetric and neonatal complications are notably higher in twin and triplet gestations compared to singletons.

Conclusions:

  • A significant proportion of assisted reproduction cycles result in multiple pregnancies, particularly triplets or higher.
  • Reducing the incidence of multiple pregnancies, especially high-order ones, should be a primary objective for in-vitro fertilization (IVF) and embryo transfer centers.
  • Improved outcomes for both mothers and newborns necessitate strategies to decrease multiple gestation rates in ART.

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