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Dual-isotope protocol for indium-111 capromab pendetide monoclonal antibody imaging
N L Kelty1, L E Holder, S H Khan
1Department of Radiology, University of Maryland Medical Center, Baltimore 21201-1595, USA.
Objective:
A dual-isotope imaging protocol using 99mTc-labeled red blood cells with 111In capromab pendetide monoclonal antibody imaging for detective and localizing nodal metastasis in prostate cancer is described.
Methods:
This protocol involves a single SPECT acquisition that is less time consuming and more comfortable for the patient than the currently recommended method, which requires two separate SPECT acquisitions performed on different days.
Results:
Forty patients were studied with the dual-isotope protocol. Preliminary data suggest increased accuracy compared with the single-isotope technique.
Conclusion:
The dual-isotope technique assures the precise image registration needed for accurate comparison of blood pool and pelvic lymph node activity that is required for confident and accurate image interpretation.
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