Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Back pain. Experimental studies are successful]

K Olmarker1

  • 1Avdelningen för ortopedi, Göteborgs Universitet, Sahlgrenska Sjukhuset.

Nordisk Medicin
|October 2, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of inflammation/pain-related genes in the dorsal root ganglion following disc puncture in rats.

Journal of orthopaedic surgery (Hong Kong)·2016
Same author

A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits.

The Journal of hand surgery, European volume·2011
Same author

Indomethacin blocks the nucleus pulposus-induced effects on nerve root function. An experimental study in dogs with assessment of nerve conduction and blood flow following experimental disc herniation.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2004
Same author

Nucleus pulposus-induced nerve root injury: effects of diclofenac and ketoprofen.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2002
Same author

Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2002
Same author

Radicular pain - recent pathophysiologic concepts and therapeutic implications.

Schmerz (Berlin, Germany)·2002
Same journal

[Nordisk Medicine 1929-1998. Thanks and farewell!].

Nordisk medicin·1999
Same journal

[Scientific fraud and misconduct--need for comprehensive terminology].

Nordisk medicin·1999
Same journal

[Labor-market for Scandinavian physicians in the year 2000--dearth or surplus?].

Nordisk medicin·1999
Same journal

[Internet in consultation--headed for trouble?].

Nordisk medicin·1999
Same journal

[Interpretation of questionnaires. An translation method problem].

Nordisk medicin·1999
Same journal

[Assessment of patients' health status--review of the literature and assessment methods].

Nordisk medicin·1999
See all related articles

Sciatica caused by disc herniation involves nerve root injury from nucleus pulposus, similar to mechanical damage. Future treatments may target these specific mechanisms pharmacologically.

Area of Science:

  • Orthopaedics
  • Neuroscience
  • Pharmacology

Background:

  • Sciatica is a common condition often caused by lumbar disc herniation.
  • The exact pathophysiological mechanisms of nerve root injury in sciatica are not fully understood.
  • Current treatments primarily address mechanical compression and inflammation.

Purpose of the Study:

  • To systematically assess the pathophysiological mechanisms of sciatica due to disc herniation.
  • To investigate the role of nucleus pulposus in nerve root injury.
  • To explore potential future pharmacological treatments for sciatica.

Main Methods:

  • Experimental studies were conducted at the Department of Orthopaedics, Gothenburg University.
  • Systematic assessment of pathophysiological mechanisms.

Related Experiment Videos

  • Evaluation of nerve root injury induced by nucleus pulposus and mechanical deformation.

    • Main Results:

    • The epidural presence of nucleus pulposus induces structural and functional injury to adjacent nerve roots.
    • This nucleus pulposus-induced nerve injury is comparable in magnitude to mechanical deformation.
    • Identified key substances and mechanisms involved in nucleus pulposus-induced nerve injury.

    Conclusions:

    • Nucleus pulposus plays a significant role in nerve root injury in sciatica.
    • Understanding these mechanisms opens avenues for targeted pharmacological interventions.
    • Future sciatica treatment may combine pharmacologic agents with existing modalities.