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[Iodine deficiency in cardiovascular diseases]
Insights
Iodine deficiency is common in patients with cardiovascular disease, particularly those with arrhythmia or heart failure. Supplementation may help prevent worsening cardiovascular conditions linked to low iodine levels.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Context:
- Thyroid hormone deficiency impacts cardiovascular function, leading to reduced myocardial contractility and increased vascular resistance.
- Cardiovascular diseases encompass conditions like hypertension, heart failure, cardiomyopathy, coronary dysfunction, and arrhythmia.
- Lipid metabolism alterations are also associated with thyroid hormone imbalances.
Purpose:
- To investigate the potential role of iodine insufficiency as a risk factor in cardiovascular diseases.
- To assess iodine levels in patients with various cardiovascular conditions.
Summary:
- This study examined 42 cardiovascular disease patients, measuring urine iodine concentration using the Sandell-Kolthoff reaction.
- Lower iodine levels were most pronounced in patients with arrhythmia and congestive heart failure.
- Elevated TSH levels were observed in 3 patients, and altered lipid metabolism was noted in subgroups without arrhythmia.
Impact:
- Iodine deficiency is frequently observed in individuals with cardiovascular disease.
- Iodine supplementation could potentially mitigate the adverse cardiovascular effects of iodine deficiency.
- Findings suggest a link between iodine status and cardiovascular health, warranting further research and clinical consideration.
Abstract:
The thyroid hormone deficiency on cardiovascular function can be characterized with decreased myocardial contractility and increased peripheral vascular resistance as well as with the changes in lipid metabolism. 42 patients with cardiovascular disease (mean age 65 +/- 13 yr, 16 males) were investigated if iodine insufficiency can play a role as a risk factor for the cardiovascular diseases. The patients were divided in 5 subgroups on the ground of the presence of hypertension, congestive heart failure, cardiomyopathy, coronary disfunction and arrhythmia. Urine iodine concentration (5.29 +/- 4.52 micrograms/dl) was detected with Sandell-Kolthoff colorimetric reaction. The most decreased urine iodine concentration was detected in the subgroups with arrhythmia and congestive heart failure (4.7 +/- 4.94 micrograms/dl and 4.9 +/- 4.81 micrograms/dl, respectively). An elevated TSH level was found by 3 patients (5.3 +/- 1.4 mlU/l). An elevation in lipid metabolism (cholesterol, triglyceride) associated with all subgroups without arrhythmia. In conclusion, the occurrence of iodine deficiency in cardiovascular disease is frequent. Iodine supplementation might prevent the worsing effect of iodine deficiency on cardiovascular disease.