Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Marginal vacuoles in thyroid aspirates

D K Das1, S Jain, R P Tripathi

  • 1Institute of Cytology and Preventive Oncology, New Delhi, India.

Acta Cytologica
|October 2, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative evaluation of loop-mediated isothermal amplification (LAMP) assay, GeneXpert MTB/Rif and multiplex PCR for the diagnosis of tubercular lymphadenitis in HIV-infected patients of North India.

Molecular and cellular probes·2019
Same author

The eyes don't see what the mind doesn't know: Pleural endometriosis on effusion cytology.

Cytopathology : official journal of the British Society for Clinical Cytology·2018
Same author

Proximal-type epithelioid sarcoma of the vulva: Cytopathological diagnosis of a rare neoplasm.

Cytopathology : official journal of the British Society for Clinical Cytology·2018
Same author

Giant cell tumour of tendon sheath: A 10-year study from a tertiary care centre.

Cytopathology : official journal of the British Society for Clinical Cytology·2018
Same author

Mediastinal hydatidosis: Fine needle aspiration and liquid-based cytology.

Cytopathology : official journal of the British Society for Clinical Cytology·2017
Same author

The role of the cytopathologist in subtyping and epidermal growth factor receptor testing in non-small cell lung cancer: An institutional experience.

Cytopathology : official journal of the British Society for Clinical Cytology·2017
Same journal

The Development Path of Gynecological Cytology after Papanicolaou: from Bethesda to Artificial Intelligence and Personalized Medicine.

Acta cytologica·2026
Same journal

Cytological Features of CIC-rearranged Sarcoma. A Report of 5 New Cases and Review of the Literature.

Acta cytologica·2026
Same journal

Pericardial Fluid Metastatic Tumor Distribution and Fluid Volume Analysis, a 10-Year Institutional Experience.

Acta cytologica·2026
Same journal

The cytopathology of infectious disease: A review.

Acta cytologica·2026
Same journal

Investigation of a storage method for peritoneal and pleural effusion cytology specimens for long-term preservation of antigenicity in immunocytochemical staining.

Acta cytologica·2026
Same journal

Diagnostic Utility of endoscopic crush cytology in gastrointestinal malignancies.

Acta cytologica·2026
See all related articles

Marginal vacuoles (MVs) in fine needle aspiration smears can indicate metastatic follicular thyroid carcinoma (FTC). This cytologic feature was observed in two metastatic FTC cases and in a significant percentage of solitary nodular goiters.

Area of Science:

  • Cytopathology
  • Endocrinology
  • Oncology

Background:

  • Follicular thyroid carcinoma (FTC) is a common endocrine malignancy.
  • Solitary nodular goiters (SNGs) are frequently encountered in clinical practice.
  • Marginal vacuoles (MVs) are a specific cytologic feature observed in thyroid fine needle aspiration (FNA) smears.

Observation:

  • Two cases of metastatic FTC presented with MVs in FNA smears from extra-thyroidal masses (hip and scalp).
  • MVs were identified in 42.6% of hyperplastic nodules within SNGs, a significantly higher rate than in colloid or neoplastic goiters.
  • MVs were predominantly found in neoplasms with a follicular component, including follicular variant of papillary carcinoma (FVPC).

Findings:

  • The presence of MVs in FNA smears aided in the diagnosis of metastatic FTC in cases where the primary thyroid tumor was not initially apparent.

Related Experiment Videos

  • The prevalence of MVs varied significantly across different types of SNGs, being highest in thyrotoxic goiter and lowest in colloid goiter.
  • MVs were significantly associated with follicular-derived neoplasms, particularly FVPC, suggesting a potential role in differentiating thyroid lesions.

    • Implications:

    • Identifying MVs in FNA smears can be crucial for diagnosing metastatic FTC, especially in cases with unknown primary tumors.
    • The differential diagnostic value of MVs in SNGs warrants further investigation for improved classification of thyroid nodules.
    • This cytologic feature may contribute to a better understanding of the histogenesis and behavior of follicular thyroid neoplasms.