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White matter abnormalities in tuberous sclerosis complex
P D Griffiths1, P Bolton, C Verity
1Academic Department of Radiology, University of Sheffield, UK.
Acta Radiologica (Stockholm, Sweden : 1987)
|October 2, 1998
Summary
White matter abnormalities are common in children with tuberous sclerosis complex (TSC), often linked to cortical tubers. MR imaging reveals diverse TSC-related white matter changes, including gliosis and hypomyelination.
Area of Science:
- Pediatric Neurology
- Neuroimaging
- Genetics
Background:
- Tuberous sclerosis complex (TSC) is a genetic disorder.
- TSC can affect multiple organs, including the brain.
- White matter abnormalities are a known feature of TSC.
Purpose of the Study:
- To investigate and describe the spectrum of white matter abnormalities in pediatric TSC patients.
- To correlate imaging findings with the disease.
Main Methods:
- Retrospective cross-sectional study.
- MR imaging analysis of 20 pediatric TSC cases (age ≤ 17 years).
Main Results:
- 95% of TSC patients showed white matter abnormalities.
- Abnormalities were most frequent near supratentorial cortical tubers.
- Other findings included radial migration lines, white matter cysts, and stroke.
Conclusions:
- MR imaging demonstrates a range of white matter abnormalities in pediatric TSC.
- Gliosis and hypomyelination near tubers are common.
- Radial migration lines may represent heterotopic glia/neurons.