Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cartilage changes caused by a coronal surface stepoff in a rabbit model

G Lovász1, A Llinás, P D Benya

  • 1Orthopaedic Research Center, Orthopaedic Hospital, Los Angeles, CA 90007, USA.

Clinical Orthopaedics and Related Research
|October 2, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of universal use of the McGrath videolaryngoscope as the first option for all intubations in the operating room: The multicentre prospective before-after VIDEOLAR-SURGERY study protocol.

Revista espanola de anestesiologia y reanimacion..·2024
Same author

Estimation of the post-mortem interval of human skeletal remains using Raman spectroscopy and chemometrics.

Forensic science international·2021
Same author

[Bearing surfaces in primary hip arthroplasty. Is there any difference?]

Acta ortopedica mexicana·2020
Same author

Critically ill COVID-19 patients attended by anesthesiologists in northwestern Spain: a multicenter prospective observational study.

Revista espanola de anestesiologia y reanimacion·2020
Same author

[How to select a prosthesis for a primary hip replacement? Minimum acceptable survival: results of a consensus of experts].

Acta ortopedica mexicana·2018
Same author

Automatic CDR Estimation for Early Glaucoma Diagnosis.

Journal of healthcare engineering·2017

Articular cartilage defects in rabbits showed adaptive remodeling rather than degeneration. A 0.5 mm stepoff defect in the femoral condyle demonstrated cartilage repair and proteoglycan synthesis recovery within six months.

Area of Science:

  • Orthopedics
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Articular surface incongruity is a key factor in joint degeneration.
  • Understanding cartilage response to defects is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the long-term effects of a controlled articular cartilage defect (stepoff) in a rabbit model.
  • To evaluate the remodeling, degeneration, and repair processes following induced incongruity.

Main Methods:

  • Created 0.5 mm coronal stepoff defects on rabbit medial femoral condyles.
  • Analyzed tissue histology (H&E, Safranin O), autoradiography (35SO4 uptake), and immunohistology (3-B-3(-), 7-D-4 epitopes) at 3, 6, 12, and 24 weeks.
  • Assessed cartilage adaptation, proteoglycan synthesis, and chondroitin sulfate epitope expression.

Related Experiment Videos

Main Results:

  • Observed permanent adaptive remodeling, including flap formation and increased cartilage height on the low side.
  • No significant degeneration was noted in the defect area or opposing tibial cartilage.
  • Autoradiography revealed a three-phase response: initial increase, decline, and late recovery of proteoglycan synthesis.
  • Immunohistology showed a decrease in 3-B-3(-) and sustained elevation of 7-D-4 near the lesion.

Conclusions:

  • A 0.5 mm femoral stepoff defect in rabbits can remodel without causing degeneration within six months.
  • The joint demonstrates adaptive mechanisms and partial recovery of proteoglycan synthesis.
  • This model provides insights into cartilage repair and the potential for non-degenerative outcomes in stable joints.