Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic analysis of dofetilide-induced changes in ventricular repolarization

G Lande1, P Maison-Blanche, J Fayn

  • 1Department of Cardiology, Lariboisière Hospital, Paris, France.

Clinical Pharmacology and Therapeutics
|October 3, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytochrome P-450-mediated herb and food-drug interactions can be identified in cancer patients through patient self-reporting with a tablet application: results of a prospective observational study.

ESMO open·2022
Same author

Monitoring of plasma concentrations of dabrafenib and trametinib in advanced BRAFV600<sup>mut</sup> melanoma patients.

Annales de dermatologie et de venereologie·2021
Same author

From electrophysiological exploration to management of heart arrhythmias: Economic analysis of practices in a high-volume French hospital over two different time periods.

Annales pharmaceutiques francaises·2020
Same author

Androgenic effects on ventricular repolarization: A translational study from the international pharmacovigilance database to iPSC-cardiomyocytes.

Annales d'endocrinologie·2020
Same author

Clinical pharmacology of anti-angiogenic drugs in oncology.

Critical reviews in oncology/hematology·2017
Same author

Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin.

Journal of thrombosis and haemostasis : JTH·2016
Same journal

Epcoritamab Step-Up Dosing Regimen Selection and Optimization Using Repeated Time-to-Event Modeling for Cytokine Release Syndrome Risk Mitigation.

Clinical pharmacology and therapeutics·2026
Same journal

From Executor to Orchestrator: The Pharmacology Scientist in the Age of Agentic AI.

Clinical pharmacology and therapeutics·2026
Same journal

The Future of Clinical Pharmacology: The Right Medicine at the Right Dose for Each Patient.

Clinical pharmacology and therapeutics·2026
Same journal

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE-Mediated Renal Drug-Drug Interactions in Healthy Volunteers.

Clinical pharmacology and therapeutics·2026
Same journal

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist.

Clinical pharmacology and therapeutics·2026
Same journal

Symposium Report: Stakeholders' Perspectives on Phase 1 Trials in Japanese Prior to Multi-Regional Clinical Trials and Future Pathways.

Clinical pharmacology and therapeutics·2026
See all related articles

Dofetilide prolongs QT intervals, with this effect decreasing at faster heart rates but persisting even at rapid heart rates. Dynamic electrocardiographic (ECG) techniques effectively detect these drug-induced repolarization changes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Electrophysiology

Background:

  • The impact of heart rate on QT prolongation caused by dofetilide, a Class III antiarrhythmic, is debated.
  • Understanding rate-dependent effects is crucial for assessing drug safety and efficacy.

Purpose of the Study:

  • To investigate how heart rate influences dofetilide-induced QT prolongation in healthy volunteers.
  • To evaluate the utility of dynamic electrocardiographic (ECG) techniques in detecting drug-induced repolarization changes.

Main Methods:

  • Ten healthy volunteers underwent 24-hour ECG recordings, with and without dofetilide administration.
  • QT interval versus R-R interval relationships were analyzed during high (Dh) and low (D1) dofetilide concentrations.
  • The slope of the QT-R-R relation served as an index for rate-dependent QT prolongation.

Related Experiment Videos

Main Results:

  • Dofetilide caused a mean 12% increase in ventricular repolarization during high drug concentration (Dh).
  • QT prolongation exhibited reverse rate dependence, increasing with longer R-R cycles (slower heart rates).
  • Significant QT prolongation persisted even at a short R-R cycle of 600 ms.

Conclusions:

  • Dofetilide prolongs the QT interval, and this effect is partially modulated by heart rate.
  • The reverse rate dependence of dofetilide's effect is incomplete, with notable prolongation remaining at rapid heart rates.
  • Dynamic ECG analysis is a valuable tool for identifying subtle, drug-induced alterations in ventricular repolarization.