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[S100B: pathogenetic and pathophysiologic significance in neurology]
1Neurologische Klinik und Poliklinik, Rheinische Friedrich-Wilhelms Universität Bonn.
Der Nervenarzt
|October 3, 1998
Summary
The S100B protein influences cell growth and has neurotrophic properties. Its overexpression is linked to Alzheimer's disease, Down syndrome, and potentially multiple sclerosis.
Area of Science:
- Biochemistry and Molecular Biology
- Neuroscience
Context:
- S100B is a calcium-binding protein involved in cellular regulation.
- It exhibits neurotrophic properties and stimulates glial cell proliferation.
Purpose:
- To review the biochemical, molecular, and functional properties of S100B.
- To explore its potential pathogenetic role in neurodegenerative diseases.
Summary:
- S100B modulates intracellular proteins, affecting cell growth, differentiation, and metabolism.
- Overexpression is implicated in Alzheimer's disease and Down syndrome plaque formation.
- S100B-specific T-cells are encephalitogenic and may be autoantigens in multiple sclerosis.
Impact:
- Highlights S100B's multifaceted roles in cellular processes.
- Establishes S100B as a potential key player in Alzheimer's, Down syndrome, and multiple sclerosis pathogenesis.
- Suggests S100B as a therapeutic target for neurodegenerative conditions.