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Related Experiment Videos

Phencyclidine: tissue distribution in the rat

S H James, S H Schnoll

    Clinical Toxicology
    |January 1, 1976
    PubMed
    Summary

    Phencyclidine (PCP) is lipophilic, accumulating in rat adipose tissue and brain long after clearing from blood. This distribution correlates with PCP

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Neuroscience

    Background:

    • Phencyclidine (PCP) is a dissociative anesthetic with known psychoactive effects.
    • Understanding PCP's tissue distribution is crucial for explaining its prolonged clinical manifestations.

    Purpose of the Study:

    • To investigate the tissue distribution of phencyclidine (PCP) in rats.
    • To correlate PCP's distribution patterns with its observed clinical effects over time.

    Main Methods:

    • Determining PCP levels in blood, brain, and adipose tissue of rats.
    • Analyzing tissue distribution at various time points over a 48-hour period.

    Main Results:

    • Phencyclidine (PCP) exhibits significant lipophilicity.
    • PCP demonstrates a high affinity for adipose tissue.
    • PCP remains detectable in brain tissue for extended periods after it is no longer found in blood.

    Conclusions:

    • The lipophilic nature of PCP drives its distribution into fatty tissues and the brain.
    • Prolonged brain presence of PCP likely contributes to delayed or persistent clinical effects observed 24-48 hours post-administration.

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