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Related Experiment Videos

Permanent pervenous atrial pacing

N P Smyth

    Comprehensive Therapy
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    A novel J-lead with silastic tines offers secure atrial fixation and reliable pacing. Animal and human studies demonstrate excellent tissue integration and long-term stability without dislodgement.

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    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Devices
    • Implantable Electrodes

    Background:

    • Traditional pacing leads can suffer from dislodgement and suboptimal tissue integration.
    • There is a need for improved atrial lead designs that ensure stable, long-term fixation.

    Purpose of the Study:

    • To introduce and evaluate a novel J-lead designed for enhanced atrial fixation using silastic tines.
    • To assess the performance and safety of this new J-lead in both animal models and human clinical trials.

    Main Methods:

    • A new J-lead incorporating proximal silastic tines for entanglement in trabeculae was designed and manufactured.
    • Pre-clinical evaluation was conducted in ten dogs, assessing tissue fixation, scarring, and electrical parameters.
    • Clinical evaluation involved 12 human patients, monitoring pacing stability, lead function, and dislodgement over extended follow-up periods.

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    Main Results:

    • Canine studies showed excellent tissue fixation at the tine site with minimal scarring at the electrode site.
    • P-wave amplitude and stimulating thresholds remained good in dogs for 4-5 months.
    • In 12 human patients, the J-lead demonstrated successful atrial pacing (P-wave-triggered, fixed-rate, or A-V synchronized) for up to 19 months, with no instances of lead dislodgement.

    Conclusions:

    • The novel J-lead with silastic tines provides secure and stable atrial fixation.
    • This design ensures reliable long-term atrial pacing performance with a low complication profile.