[The evaluation of cellular immunity in patients with allergy to pollen]

The study comprised 180 patients with pollinosis, 30 patients with vasomotor rhinitis and 30 healthy male adults. The skin reactions of cellular immunity were determined by Multitest CMI. The numbers of lymphocytes T and numbers of CD4 and CD8 lymphocytes were determined under influence of histamine or clemastinum and histamine or cimetidine and histamine. There were statistically significant decrease of percentage of CD8 lymphocytes in patients with pollinosis after addition of histamine. Statistically significant increase of percentage of CD8 lymphocytes after the addition of H2 receptor blocker indicated that blocking of this receptor neutralized the effect of histamine on the CD8 lymphocytes. Author observed increase of Multitest CMI skin reactions (particularly for antigens: Streptococcus and Proteus mirabilis).