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A randomized comparison of the methods of sperm preparation for intrauterine insemination
W C Dodson1, J Moessner, J Miller
1Division of Obstetrics and Gynecology, University Hospital, Penn State Geisinger Health System, Hershey, Pennsylvania, USA.
Objective:
To compare the effectiveness of three methods of sperm preparation for IUI during superovulation of infertile women.
Design:
Randomized assignment of one of three sperm preparation methods.
Setting:
University infertility practice.
Patient(S):
Infertile couples undergoing superovulation and IUI.
Intervention(S):
The method of preparation of sperm for IUI during superovulation was assigned randomly to double centrifugation, multiple-tube swim-up, or Percoll density gradient.
Main Outcome Measure(S):
Total number and percent recovery of motile sperm, percent of recovered sperm with normal morphology, and cycle fecundity.
Result(S):
No method of sperm preparation provided better cycle fecundity than the others despite differences in sperm recovery.
Conclusion(S):
Double centrifugation, multiple-tube swim-up, and Percoll density gradient sperm preparation for IUI yield similar cycle fecundity rates.