Metatarsal growth during the second trimester: a predictor of gestational age?

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...

Physical development during the prenatal period and early childhood follows two major directional principles: cephalocaudal and proximodistal development. These general patterns happen simultaneously and help explain changes in body proportions and the gradual development of motor skills.Cephalocaudal DevelopmentThe cephalocaudal principle describes development from the head downward toward the lower body. During prenatal development, the head and brain structures develop rapidly before many...

Physical growth is especially rapid during the first three years of life, with the greatest rate in the first few months after birth. Although children continue to gain height and weight throughout infancy and toddlerhood, the rate of growth gradually slows during the second and third years. At most ages, boys are typically slightly taller and heavier than girls, reflecting a common pattern of early physical development.Changes in Body ProportionsAs infants become toddlers, their body...

Children develop a wide range of gross motor skills during the first three years, as increasing muscle strength, balance, coordination, and nervous system maturation allow greater control over body movements. Development generally progresses from basic postural control to independent movement and later to activities such as jumping, climbing, and pedaling.Motor Development During the First YearMost infants begin rolling during the first several months, although the timing and direction can vary.