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Cerebrospinal fluid magnesium level as a prognostic factor in ischaemic stroke
Journal of Neurology
|October 3, 1998
Summary
Low cerebrospinal fluid (CSF) magnesium levels in the early stages of ischemic stroke correlate with increased neurological deficits and infarct size. This finding highlights magnesium
Area of Science:
- Neurology
- Neuroscience
- Biochemistry
Background:
- Magnesium (Mg+2) exhibits vasodilatory effects on cerebral arteries.
- Reduced extracellular Mg+2 is linked to cerebral vasospasm intensity.
- Magnesium's neuroprotective role in stroke is hypothesized.
Purpose of the Study:
- To investigate magnesium (Mg+2) levels in serum and cerebrospinal fluid (CSF) during the early phase of stroke.
- To evaluate the relationship between Mg+2 levels and the severity of neurological deficits.
Main Methods:
- 96 stroke patients with 24-48 hour symptom duration were enrolled.
- Serum and CSF magnesium levels were measured on admission and 24-48 hours post-stroke.
- Neurological deficits were assessed using a standardized score; infarct volume/location determined by CT scan.
Main Results:
- A significant correlation was observed between CSF Mg+2 levels and infarct size (P < 0.0001).
- No correlation was found between serum Mg+2 and CSF Mg+2 levels.
- Higher CSF Mg+2 levels were associated with improved neurological scores, even after adjusting for confounding factors.
Conclusions:
- A low CSF Mg+2 concentration within 48 hours of ischemic stroke onset is related to the intensity of neurological deficits.
- These findings suggest potential therapeutic implications for magnesium in stroke management.