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Laparoscopic biopsy for suspected abdominal lymphoma
J G Strickler1, J H Donohue, L E Porter
1Department of Anatomic Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Summary
Laparoscopic biopsy is effective for diagnosing abdominal lymphoproliferative disorders, including lymphoma. This minimally invasive approach provides sufficient tissue for accurate classification and diagnosis of other abdominal conditions.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Abdominal lymphoproliferative disorders require accurate tissue diagnosis for effective management.
- Minimally invasive techniques are preferred for obtaining diagnostic tissue samples.
Purpose of the Study:
- To evaluate the diagnostic yield of laparoscopic biopsy in patients with suspected abdominal lymphoproliferative disorders.
- To assess the ability of laparoscopic techniques to diagnose lymphoma and other neoplasms.
Main Methods:
- Retrospective review of laparoscopic biopsy specimens from 51 patients.
- Histologic evaluation supplemented by immunohistochemistry and Southern blot hybridization.
- Analysis of diagnostic success rates and reasons for technical failure.
Main Results:
- Laparoscopic biopsy was diagnostic in 47% of patients with lymphoproliferative disorders, 10% with other neoplasms, and 22% with reactive tissue.
- Lymphoma was diagnosed in 14 new cases and 10 recurrent cases, including diffuse large cell and follicular lymphoma.
- Previous biopsies were inconclusive in 11 lymphoma patients, highlighting the value of laparoscopic sampling.
Conclusions:
- Laparoscopic biopsy is a valuable tool for diagnosing and classifying abdominal lymphomas.
- The procedure provides sufficient tissue for diagnosing various lymphoproliferative disorders and other causes of abdominal lymphadenopathy.
- Laparoscopic techniques offer a high diagnostic yield in suspected cases, potentially avoiding more invasive procedures.