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[A study of correlation between essential hypertension and HLA-DQA1 alleles]
1Cardiovascular Division, People's Hospital, Beijing Medical University, Beijing, 100044 P. R. China.
Abstract
Objective:
To analyse the hereditary susceptibility by genotyping of HLA-DQA1 alleles in essential hypertensives.
Methods:
The allelic types of HLA-DQA1 were detected by PCR-SSP technic in 52 cases of essential hypertensives and 86 normal individuals as the control.
Results:
The frequency of HLA-DQA1*0302 allele in hypertensive group was markedly higher than that in normal control group (17.9572 vs 3.5531), but the frequency of HLA-DQA1*0103 allele in normal group was higher than that in hypertensive group.
Conclusion:
HLA-DQA1*0302 may be a correlative gene of essential hypertension, whereas HLA-DQA1*0103 may be a defence gene of hypertension.