Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroids during pregnancy

M D Lockshin1, L R Sammaritano

  • 1Cornell University Medical College, Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, New York, NY 10021, USA.

Scandinavian Journal of Rheumatology. Supplement
|October 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal evaluation of diffusion tensor imaging and cognition in systemic lupus erythematosus.

Lupus·2018
Same author

Bleeding complications and antithrombotic treatment in 264 pregnancies in antiphospholipid syndrome.

Lupus·2018
Same author

Feasibility of Patient-Reported Outcomes Measurement Information System (PROMIS®) computerized adaptive tests in systemic lupus erythematosus outpatients.

Lupus·2018
Same author

Functional Magnetic Resonance Imaging of Working Memory and Executive Dysfunction in Systemic Lupus Erythematosus and Antiphospholipid Antibody-Positive Patients.

Arthritis care & research·2016
Same author

Assisted reproductive technology in SLE and APS.

Lupus·2014
Same author

Contraception in patients with systemic lupus erythematosus and antiphospholipid syndrome.

Lupus·2014
Same journal

Abstract of the 35th Scandinavian Congress of Rheumatology, September 20-23, 2014, Stockholm, Sweden.

Scandinavian journal of rheumatology. Supplement·2014
Same journal

Abstracts of the 34th Scandinavian Congress of Rheumatology. Copenhagen, Denmark. September 2-5, 2012.

Scandinavian journal of rheumatology. Supplement·2012
Same journal

How should impaired morning function in rheumatoid arthritis be treated?

Scandinavian journal of rheumatology. Supplement·2011
Same journal

Morning stiffness and other patient-reported outcomes of rheumatoid arthritis in clinical practice.

Scandinavian journal of rheumatology. Supplement·2011
Same journal

How should morning function in rheumatoid arthritis be assessed? Bibliographic study of current assessment.

Scandinavian journal of rheumatology. Supplement·2011
Same journal

How much is a reduction in morning stiffness worth to patients with rheumatoid arthritis?

Scandinavian journal of rheumatology. Supplement·2011
See all related articles

Systemic corticosteroids are generally safe during pregnancy, offering benefits and side effects similar to non-pregnant individuals. While typically not teratogenic, potential risks like low birth weight and premature rupture of membranes exist with corticosteroid use.

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Neonatology

Background:

  • Pharmacokinetics of corticosteroids are altered during pregnancy.
  • Systemic corticosteroids are not considered teratogenic.
  • Maternal corticosteroid therapy presents similar benefits and side effects as in non-pregnant patients.

Purpose of the Study:

  • To review the safety and efficacy of corticosteroid use during pregnancy.
  • To outline appropriate indications for corticosteroid therapy in pregnant patients.
  • To discuss the effects of maternal corticosteroid use on fetal outcomes and neonatal health.

Main Methods:

  • Review of existing clinical data and literature on corticosteroid use in pregnancy.
  • Analysis of side effect profiles and benefits in pregnant versus non-pregnant populations.

Related Experiment Videos

  • Examination of specific corticosteroid agents and their fetal applications.

    • Main Results:

    • No teratogenic effects observed with usual doses of prednisone and methylprednisolone.
    • Potential risks include premature rupture of membranes and low birth weight.
    • Betamethasone and dexamethasone are utilized for fetal treatment; effects of methylprednisolone bolus doses are unknown.
    • Minimal corticosteroid transfer into breast milk.

    Conclusions:

    • Corticosteroid therapy is appropriate in pregnancy for active maternal illness, fetal conditions like neonatal lupus carditis, stress doses, and fetal lung maturation.
    • Careful consideration of risks and benefits is necessary for optimal maternal and fetal outcomes.