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[Secondary kidney amyloidosis and mucoviscidosis]
M Guillot1, B Drut-Desombre, M Amiour
1Service de pédiatrie et centre de soins mucoviscidose, centre hospitalier général, Lisieux, France.
Background:
Due to the improvement in cystic fibrosis management, life expectancy has risen; on the other hand, longer survival has led to new complications, including secondary renal amyloidosis, which has been so far very uncommonly reported.
Case Reports:
Secondary nephropathic amyloidosis was seen in two 25-year and 22-year-old adults with cystic fibrosis. Both had developed recurrent pulmonary infections due to Pseudomonas aeruginosa over several years. One patient died after 2 years of progressive kidney failure.
Conclusion:
Severe renal insufficiency due to secondary amyloidosis may complicate the course of cystic fibrosis and become the main prognosis factor in adults.