Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantal analysis of synaptic processes in the neocortex

A M Thomson1

  • 1Department of Physiology, Royal Free Hospital School of Medicine, London, UK.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|October 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of blood flow restriction training timing: Does exercising at dusk or dawn enhance response?

Physiological reports·2025
Same author

Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes.

The British journal of surgery·2021
Same author

Maternal stature and reproductive efficiency.

The Eugenics review·2011
Same author

A feeding experiment among Indian Army recruits.

The Indian journal of medical research·2010
Same author

Post-partum Retinal Arterial Obstruction with Hemiplegia.

British medical journal·2010
Same author

Growth and Mortality in Children in an African Village.

British medical journal·2010
Same journal

[Risk of accidents for a Parisian pedestrian].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2002
Same journal

Differences in the social context of song production in captive male and female European starlings.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2002
Same journal

[Predictive value of biological species for plant conservation in the Mediterranean area].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2002
Same journal

[Biological quality of seawater evaluated in situ with embryo-larval test of Crassostrea gigas and Mytilus galloprovincialis].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2002
Same journal

Removal of cell-bound lipoproteins: a crucial step for the efficient infection of liver cells with hepatitis C virus in vitro.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2002
Same journal

[Contribution of experimental models to the understanding of immunity to schistosomiasis].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2002
See all related articles

Fluctuation analysis reveals presynaptic and postsynaptic contributions to synaptic efficacy changes. This method, combined with ultrastructural analysis, estimates quantal size and release probability, crucial for understanding synaptic function in the neocortex.

Area of Science:

  • Neuroscience
  • Synaptic Physiology
  • Cellular Electrophysiology

Background:

  • Synaptic efficacy changes are fundamental to neural computation.
  • Distinguishing presynaptic and postsynaptic contributions is crucial for understanding synaptic plasticity.
  • Fluctuation analysis offers a quantitative approach to dissect synaptic transmission.

Purpose of the Study:

  • To discuss the application of fluctuation analysis in neocortical synaptic studies.
  • To evaluate the utility of transmission failure analysis in identifying the site of synaptic efficacy changes.
  • To explore how ultrastructural verification aids in estimating quantal parameters.

Main Methods:

  • Application of fluctuation analysis to synaptic transmission.
  • Analysis of transmission failures.

Related Experiment Videos

  • Ultrastructural verification of synaptic connections.
  • Estimation of quantal size and release probability.

    • Main Results:

    • Fluctuation analysis effectively differentiates presynaptic from postsynaptic roles in synaptic efficacy modulation.
    • Combined with ultrastructural data, it provides reliable estimates of quantal size and release probability at low frequencies.
    • At higher frequencies, release site availability and release probability exhibit variability, influenced by distinct presynaptic mechanisms.
    • Different connection classes show varying sensitivities to firing frequency due to distinct release modulation mechanisms.

    Conclusions:

    • Fluctuation analysis is a powerful tool for dissecting synaptic function in the neocortex.
    • Understanding frequency-dependent modulation of release is key to comprehending dynamic synaptic behavior.
    • Presynaptic mechanisms exhibit diverse strategies for regulating neurotransmitter release based on firing frequency.