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[Similarities between angiogenesis and neoplasm invasiveness ]
1UMR319, Institut de Biologie de Lille. stehelin@infobiogen.fr
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|October 6, 1998
Summary
Cytokines induce Ets transcription factors in endothelial cells during neovascularization and in tumor-associated fibrocytic cells. These factors up-regulate genes for matrix metalloproteinases, crucial for tumor invasion and blood vessel growth.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Context:
- Cytokine signaling pathways
- Tumor microenvironment
- Neovascularization processes
Purpose:
- Investigate the role of Ets transcription factors in neovascularization and tumor invasion
- Elucidate the molecular mechanisms underlying gene expression in response to cytokines
- Identify potential therapeutic targets for inhibiting tumor expansion and angiogenesis
Summary:
- Cytokines induce Ets family transcription factors in endothelial cells during neovascularization and in invasive tumor-associated fibrocytic cells.
- In invasive tumors, fibrocytic cells express metalloproteinases (e.g., collagenase 1, uPA, stromelysin1) regulated by Ets factors, often with Jun/Fos complexes.
- Ex vivo experiments confirm direct Ets-mediated upregulation of genes involved in stromal remodeling, facilitating tumor expansion.
Impact:
- Ets transcription factors are key regulators of both neovascularization and tumor invasion.
- Targeting Ets factors may offer a strategy to inhibit tumor expansion and angiogenesis.
- Understanding these pathways provides insights into tumor microenvironment dynamics and therapeutic interventions.