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[Retinal vein occlusion and lipoprotein (a)]
F Ribeaudeau-Saindelle1, A Glacet-Bernard, F Lelong
1Clinique Ophtalmologique Universitaire de Créteil, Centre Hospitalier Intercommunal, Créteil.
Journal Francais D'Ophtalmologie
|October 6, 1998
Summary
Elevated lipoprotein (a) levels are significantly higher in patients with retinal vein occlusion compared to controls. This suggests a potential link between lipoprotein (a) and retinal vascular disease, warranting further investigation.
Area of Science:
- Ophthalmology
- Cardiovascular Science
- Hematology
Context:
- Retinal vein occlusion (RVO) is a significant cause of vision loss.
- Elevated lipoprotein (a) [Lp(a)] is a known risk factor for cardiovascular and cerebrovascular diseases.
- Lp(a) shares structural similarities with plasminogen, potentially impacting fibrinolysis.
Purpose:
- To investigate the association between elevated lipoprotein (a) levels and the occurrence of retinal vein occlusion.
- To determine if Lp(a) levels correlate with the severity or type of RVO.
Summary:
- A study of 132 RVO patients and 52 controls found significantly higher Lp(a) levels in the RVO group (p=0.05).
- Elevated Lp(a) (> 0.1 g/l) was more prevalent in RVO patients (61%) than controls (42%; p<0.02).
- No correlation was observed between high Lp(a) and RVO severity or type (central vs. branch).
Impact:
- Lipoprotein (a) may play a role in the pathogenesis of retinal vein occlusion, potentially through fibrinolytic system dysfunction.
- Further research is needed to fully elucidate the role of Lp(a) in RVO and its prognostic value.