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Ischemic colitis and sumatriptan use

J F Knudsen1, B Friedman, M Chen

  • 1Division of Neuropharmacologic Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA.

Archives of Internal Medicine
|October 6, 1998
PubMed
Summary
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Sumatriptan succinate, a migraine treatment, may cause ischemic colitis. This serious side effect involves reduced blood flow to the colon, distinct from its intended cranial effects.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Cardiology

Background:

  • Sumatriptan succinate is a selective serotonin-1 (5-HT1) receptor agonist used for acute migraine treatment.
  • It is known to cause cranial vasoconstriction, but systemic vasopressor responses have also been observed.
  • Previous reports linked sumatriptan to coronary vasospasm, myocardial ischemia, and myocardial infarction.

Observation:

  • This study reports on 8 patients who developed ischemic colitis after sumatriptan administration.
  • The observed cases highlight a potential gastrointestinal adverse effect of sumatriptan.
  • Ischemic colitis is a condition characterized by inflammation and tissue damage in the colon due to reduced blood supply.

Findings:

  • Sumatriptan use was associated with the development of serious ischemic colitis in a cohort of migraine patients.

Related Experiment Videos

  • These findings suggest that sumatriptan can induce vasospasm in the mesenteric circulation, leading to colonic ischemia.
  • The adverse events were distinct from the drug's intended effects on intracranial arteries.

    • Implications:

    • Clinicians should be aware of the risk of ischemic colitis when prescribing sumatriptan.
    • Further research is warranted to elucidate the mechanisms underlying sumatriptan-induced mesenteric ischemia.
    • This underscores the importance of monitoring for serious adverse events in patients using triptans for migraine management.