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Related Experiment Videos

Severe anaphylaxis from rifamycin SV

F Erel1, M Karaayvaz, M Deveci

  • 1Department of Allergy, Gülhane Military Medical Academy, Ankara, Turkey.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|October 6, 1998
PubMed
Summary
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Anaphylaxis to topical rifamycin SV is rare, but two cases show it can cause IgE-mediated reactions. Skin prick tests confirmed rifamycin SV allergy in patients, supporting its role in these rare anaphylactic events.

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Background:

  • Topical rifamycin SV is utilized in surgery and dermatology.
  • Anaphylaxis to topical rifamycin SV is considered rare.

Observation:

  • Two patients experienced systemic reactions following repeated topical rifamycin SV application.
  • Skin prick tests and Prausnitz-Küstner testing were performed.

Findings:

  • Patients exhibited positive skin prick tests to rifamycin SV, while controls were negative.
  • Prausnitz-Küstner testing indicated passive transfer and IgE-mediated mechanisms.
  • Allergy assessments for other substances were negative.

Implications:

  • These cases suggest IgE-mediated hypersensitivity to rifamycin SV can occur.

Related Experiment Videos

  • Clinicians should consider rifamycin SV allergy in patients with unexplained anaphylaxis after topical use.