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Angiotensin-converting enzyme gene polymorphism in Nepal

S Umemura1, T Kawasaki, T Ishigami

  • 1Second Department of Internal Medicine, Yokohama City University, Yokohama, Japan.

Journal of Human Hypertension
|October 6, 1998
PubMed
Summary
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Despite high salt intake, a Nepalese village showed low hypertension rates. Genetic analysis of the angiotensin-converting enzyme (ACE) gene I/D polymorphism revealed no significant association with this

Area of Science:

  • Cardiovascular Genetics
  • Population Health
  • Human Genetics

Background:

  • A Nepalese village exhibits unusually low hypertension prevalence despite high per capita salt consumption, challenging typical salt-hypertension correlations.
  • Previous research suggests the angiotensin-converting enzyme (ACE) gene I/D polymorphism influences salt sensitivity, making it a candidate for investigation.

Purpose of the Study:

  • To investigate the genotype distribution of the ACE gene I/D polymorphism in the Nepalese population.
  • To determine if ACE gene I/D polymorphism contributes to the observed 'salt resistance' in this population.

Main Methods:

  • Genotyping of the ACE gene I/D polymorphism was performed on 138 subjects from Nepal.
  • Hypertension status (blood pressure > 140/90 mm Hg) and daily salt intake were assessed.

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Main Results:

  • Only 6.5% of the studied Nepalese population were hypertensive, confirming low prevalence despite high salt intake (11 g/day).
  • The ACE gene I/D polymorphism distribution in Nepalese subjects was similar to Japanese and Chinese populations, but distinct from Caucasians.
  • This distribution pattern did not align with the high hypertension rates observed in East Asian populations with similar salt intake.

Conclusions:

  • The study provides the first report on ACE gene I/D polymorphism distribution in Nepalese individuals.
  • The findings suggest that ACE gene polymorphism is unlikely to be the primary genetic factor responsible for the observed 'salt resistance' in this Nepalese population.