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Exercise-training-induced alterations in hepatic function in mares

T M Dyke1, R A Sams, K W Hinchcliff

  • 1Analytical Toxicology Laboratory and Exercise Physiology Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210-1089, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 7, 1998
PubMed
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Exercise training significantly improved hepatic function in horses by increasing the plasma clearance of antipyrine, indicating enhanced liver metabolism. This study highlights the positive impact of regular exercise on equine health and metabolic processes.

Area of Science:

  • Equine Sports Medicine
  • Exercise Physiology
  • Hepatology

Background:

  • Hepatic function is crucial for equine health and performance.
  • Exercise training is known to induce physiological adaptations in horses.
  • Understanding the impact of exercise on liver metabolism is important for optimizing training regimens.

Purpose of the Study:

  • To investigate the effects of a standardized exercise training program on hepatic function in adult mares.
  • To assess changes in the plasma clearance and distribution of antipyrine as a marker of liver metabolism.

Main Methods:

  • Adult mares were divided into a treadmill training group (n=7) and a control group (n=6).
  • Training involved 5 weeks of exercise at 60% and 90% of maximal oxygen consumption (V(O2)max).

Related Experiment Videos

  • Plasma clearance of antipyrine was measured to evaluate hepatic function.

    • Main Results:

    • Trained horses showed significant increases in V(O2)max and velocity for a blood lactate concentration of 4 mmol/l.
    • Plasma antipyrine clearance and volume of distribution significantly increased in the trained group.
    • Untrained horses exhibited a decrease in antipyrine clearance and volume of distribution.

    Conclusions:

    • Exercise training enhances hepatic metabolism in horses, as evidenced by increased antipyrine clearance.
    • Training may also lead to an increase in total body water.
    • These findings suggest that exercise positively influences liver function and body composition in equine athletes.