Harmonization of genotoxicity testing requirements for pharmaceuticals

Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards.

Mutation research·2006

Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test.

Mutation research·2006

Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells.

Cytogenetic and genome research·2004

Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.

Mutation research·2001

Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse).

Mutation research·2000

Requirement of wild-type p53 protein for maintenance of chromosomal integrity.

Molecular carcinogenesis·2000

Linalool inhalation‒induced anxiety-like effects occur independently of olfactory input and require cytochrome P450 activity.

The Journal of toxicological sciences·2026

Protein homeostasis disruption in cisplatin-induced skeletal muscle atrophy: toxicological insights from experimental studies.

The Journal of toxicological sciences·2026

A high-fat/high-sucrose/high-cholesterol diet leads to early indications of metabolic dysfunction-associated steatohepatitis-like lesions in obese diabetic mice.

The Journal of toxicological sciences·2026

Sensitivity of respiratory cell lines to unsaturated carbonyl compounds in cigarette smoke is regulated by intracellular glutathione.

The Journal of toxicological sciences·2026

Virtual internal exposures of lansoprazole administered to cytochrome P450 2C19 poor metabolizers estimated by simplified physiologically based pharmacokinetic modeling.

The Journal of toxicological sciences·2026

A case study of virtual control group verification using historical control data at a single facility.

The Journal of toxicological sciences·2026

How are testicular functions affected after morphine dependence and withdrawal in rats?

Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi·2026

Exocytosed ATP as a therapeutic target for inflammatory and metabolic diseases.

Frontiers in pharmacology·2026

Cardiac Safety Profile of Ziprasidone: A Real-World Pharmacovigilance Study Using FAERS and Network Toxicology.

Current neuropharmacology·2026

Addiction Specialists' Knowledge About and Assessment Practices for Kratom, Phenibut, and Tianeptine.

Substance use & addiction journal·2026

Extended-release buprenorphine in adults with opioid use disorder involving poppy seed tea: An 18-month retrospective case series.

The American journal on addictions·2026

In vitro toxicity of piperazine derivatives involves mitochondrial dysfunction and microtubule-related changes in neuronal cell models.

BMC pharmacology & toxicology·2026

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Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards.

Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test.

Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells.

Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.

Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse).

Requirement of wild-type p53 protein for maintenance of chromosomal integrity.

Linalool inhalation‒induced anxiety-like effects occur independently of olfactory input and require cytochrome P450 activity.

Protein homeostasis disruption in cisplatin-induced skeletal muscle atrophy: toxicological insights from experimental studies.

A high-fat/high-sucrose/high-cholesterol diet leads to early indications of metabolic dysfunction-associated steatohepatitis-like lesions in obese diabetic mice.

Sensitivity of respiratory cell lines to unsaturated carbonyl compounds in cigarette smoke is regulated by intracellular glutathione.

Virtual internal exposures of lansoprazole administered to cytochrome P450 2C19 poor metabolizers estimated by simplified physiologically based pharmacokinetic modeling.

A case study of virtual control group verification using historical control data at a single facility.

How are testicular functions affected after morphine dependence and withdrawal in rats?

Exocytosed ATP as a therapeutic target for inflammatory and metabolic diseases.

Cardiac Safety Profile of Ziprasidone: A Real-World Pharmacovigilance Study Using FAERS and Network Toxicology.

Addiction Specialists' Knowledge About and Assessment Practices for Kratom, Phenibut, and Tianeptine.

Extended-release buprenorphine in adults with opioid use disorder involving poppy seed tea: An 18-month retrospective case series.

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Harmonization of genotoxicity testing requirements for pharmaceuticals

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