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[The role of protein C in the pathogenesis of stroke]
J Wojczal1, H Bartosik-Psujek, M Dziduch
1Katedry i Kliniki Neurologii A.M., Lublinie.
Insights
Protein C deficiency plays a role in stroke, especially in children with hereditary factors. In adults, it
Area of Science:
- Hematology
- Neurology
- Genetics
Context:
- Protein C is a crucial anticoagulant.
- Stroke is a leading cause of death and disability.
- Understanding thrombophilia risk factors is vital.
Purpose:
- To review the role of protein C deficiency in stroke pathogenesis.
- To discuss current scientific opinions on protein C and stroke.
- To differentiate risk in pediatric versus adult populations.
Summary:
- Deficiency of protein C (PC) or resistance to activated protein C (APC) contributes to stroke, though its significance is debated.
- While isolated PC deficiency poses minimal risk in older adults, hereditary PC deficiency or APC resistance is critical in pediatric ischemic or venous stroke.
- PC deficiency can be a significant contributing factor to stroke in both children and adults when additional risk factors are present.
Impact:
- Informs clinical risk assessment for stroke.
- Highlights the importance of genetic screening in pediatric stroke.
- Guides future research into thrombophilia and cerebrovascular disease.
Abstract:
This paper presents the role of inhibitory protein C in the haemostatic processes, types of its deficiency and current opinions concerning the role of protein C deficiency in the pathogenesis of stroke. Deficiency of protein C (PC) or activated protein C resistance (both hereditary and acquired) play a role in pathogenesis of stroke, but not so great as it was thought until quite lately. Isolated protein C deficiency in old patients does not increase the risk of stroke. But in children hereditary deficiency of PC or activated PC resistance are of great importance in pathogenesis of ischaemic or venous stroke. In the presence of additional risk factors both in children and in adults deficiency of PC may be an important condition leading to stroke occurrence.