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Related Experiment Videos

Tolerance induction with CD4 monoclonal antibodies

H Waldmann1, F Bemelman, S Cobbold

  • 1Sir William Dunn School of Pathology, Oxford, UK.

Novartis Foundation Symposium
|October 7, 1998
PubMed
Summary

Short-term CD4 antibody therapy induces long-term dominant tolerance, characterized by linked and transferable suppression. This approach offers a minimally invasive strategy for clinical applications in therapeutic immunosuppression.

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Area of Science:

  • Immunology
  • Transplantation

Background:

  • Therapeutic immunosuppression aims for long-term tolerance via short-term treatments.
  • Achieving dominant tolerance is a key goal in managing immune responses.

Purpose of the Study:

  • To investigate the potential of short CD4 antibody courses in inducing long-term immune tolerance.
  • To characterize the mechanisms of tolerance induced by CD4 antibodies.

Main Methods:

  • Administration of short courses of CD4 antibodies in mature immune system models.
  • Analysis of tolerance features including linked suppression, transferable suppression, and infectious tolerance.
  • Comparison with tolerance induced by high-dose marrow administration.

Main Results:

  • Short CD4 antibody courses successfully induced peripheral tolerance.
  • The induced tolerance exhibited dominant characteristics: linked suppression, transferable suppression, and infectious tolerance.
  • High-dose marrow administration induced deletional tolerance, distinct from regulatory mechanisms.

Conclusions:

  • Dominant tolerance and linked suppression via CD4 antibodies represent a promising, minimally invasive strategy for clinical immunosuppression.
  • This approach may offer a more accessible alternative to deletional tolerance induction.

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